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Abstract B166 MicroRNAs downstream of ADAM8 as

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Enoxacin Directly Inhibits Osteoclastogenesis without Inducing Apoptosis

Abstract Enoxacin has been identified as a small molecule inhibitor of binding between the B2-subunit of vacuolar ... primers for the mouse genes that encode TRAP5b (Mm00475698_m1), a3-subunit (Mm00469406_m1), l-plastin (Mm01310735_m1), ADAM8 ...

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative .

Background ADAM8 (a disintegrin and metalloproteinase 8) protein promotes the invasive and metastatic phenotype of triple-negative breast cancer (TNBC) cells. High ADAM8 expression in breast cancer patients is an independent predictor of poor prognosis. Here ...

Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis - ScienceDire

MicroRNAs can be involved in the regulation of oncogenes and tumor suppressors. miRNA targets a broad range of genes, ... These CpG-SNP pairs are strongly associated with differential expression of ADAM8, CREB5, and EXPH5 genes, respectively. The 81 ...

MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cel

MicroRNAs are important regulators of gene expression and have been suggested to play a key role in ... We cloned an 80-bp sequence containing the predicted binding site or a scrambled sequence downstream of the pMIR luciferase reporter to generate pMIR ...

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Abstract: ADAM8 is reported to promote extracellular matrix degradation to provide conditions for tumor metastasis. ... Then, by silencing or overexpressing ADAM8, the effects on cell migration and invasion in SW1353 and HCS-2/8, and the downstream signal ...

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative .

High ADAM8 expression in breast cancer patients is an independent predictor of poor prognosis. Here, we investigated whether ADAM8 regulates specific miRNAs, their roles in aggressive phenotype, ...

Multiple functions of m 6 A RNA methylation in cancer | Journal of Hematology & Oncology | Full Te

The R-2HG/FTO/m 6 A axis regulates MYC and CCAAT/enhancer-binding protein alpha (CEBPA) gene expression and downstream pathways []. ...

JoVE | Peer Reviewed Scientific Video Journal - Methods and Protoco

JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles. ... Find video protocols related to scientific articles indexed in Pubmed.

MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells - Europe PMC Article - Europe PubMed Centr

FULL TEXT Abstract: MicroRNAs are important regulators of gene expression and have been suggested to play a key role in tumorigenesis. In this study, we ...

ADAM8 as a drug target in pancreatic cancer | Nature Communicatio

Abstract Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with <5% survivors after 5 years. ... infiltration and metastasis in vivo by affecting downstream signalling of ADAM8, thus further supporting the important role of ADAM8 in PDAC. ERK1/2 ...

Using microRNA as Biomarkers of Drug-Induced Liver Injury | William F. Salminen | Request P

Request PDF on ResearchGate | On Jan 1, 2011, William F. Salminen and others published Using microRNA as Biomarkers of Drug-Induced Liver Injury ... Pharmacogenomics is the study of genetic variations between individuals to predict the risk of toxic side ...

Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human | Circulation: Genomic and .

Although we have not studied all the downstream consequences of our findings, including more detailed impact on protein, cell cycle, and in vivo validation, our work provides a platform for future studies. ...

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative .

View This Abstract Online miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple ...

More articles from Metastasis and Invasion | Molecular Cancer Therapeuti

AACR Journals Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer ...

PLOS ONE: Role of microRNA-30c Targeting ADAM19 in Colorectal Canc

Abstract MicroRNAs (miRNAs) are deregulated in a number of cancers including colorectal cancer. MiR-30c belongs to miR-30 family, and is involved in a variety of malignant diseases. In this study, we detected the expression of miR-30c in colon cancer cell lines ...

microRNA‐214 contributes to melanoma tumour progression through suppression of TFAP2C | The EMBO Journ

MicroRNAs (miRs) are endogenous non‐coding RNAs involved in tumourigenesis. Using a melanoma progression model, ... ADAM8 ADAM8 1.6 Up Y ADAM9 ADAM9 2.5 Up ALCAM/CD166 ALCAM 6.0 Up APP (pan) APP 1.8 Up Provenzano et al BCAM BCAM ...

MARKERS FOR MATURE BETA-CELLS AND METHODS OF USING THE SAME - President and Fellows of Harvard Colle

Abstract: Markers for mature β-cells and methods of using these markers are disclosed . Inventors: Melton, Douglas A. (Lexington, MA, US) Hrvatin, Sinisa (Cambridge, MA, US ...

Role of non-coding RNAs in maintaining primary airway smooth muscle cells | Respiratory Research | Full Te

Background The airway smooth muscle (ASM) cell maintains its own proliferative rate and contributes to the inflammatory response in the airways, effects that are inhibited ... Objective We determined the differential expression of mRNAs, microRNAs (miRNAs) and ...

Integrated analysis reveals candidate genes and transcription factors in lung adenocarcino

Lung adenocarcinoma is the most common type of non‑small cell lung cancer in Asia. Therefore, ... A previous study on the synergistic regulation of microRNAs (miRNAs) and TFs have identified a variety of significant motifs (). In addition, a miRNA-TF synergistic). ...

Frontiers | Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder | Psychiat

Lack of FMRP in FXS (and in some individuals with autism), would also favor PIKE activation of mTOR and downstream Rho GTPases including Rac1 and cofilin that in turn would cause actin disassembly and myelination (). ...

Cancer stem-like cells have cisplatin resistance and miR-93 regulate p21 expression in breast cancer Sasaki A, Tsunoda Y, Furuya K, Oyamada H .

study aims to examine the role of microRNAs (miRNAs) in regulating the expression of p21, a cyclin-dependent ... Jézéquel P, Campone M, Sonenshein GE. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes . ...